The Biggest game of the day, and possibly in Irish football takes place at Tallagh Stadium this evening as Shamrock Rovers take on Bohemians.
Rovers could potentially end the day on top spot, if results go their way, while Bohs are hoping to end a run of seven games without a win.
That game kicks off at 8 o'clock.
Bottom club Athlone Town have their best chance to get their first win of the season as they host UCD.
Dundalk will look to extend their lead at the top of the table with a tricky tie at home to Sligo Rovers. Dundalk midfielder Richie Towell will hope to impress once again, as interest in the former Celtic youngster grows.
Should the league leaders slip up, Cork City will be ready to pounce, if they can pick up all three points away to Bray Wanderers.
The Seagulls will look to inflict some revenge after City picked up a 3-1 win against Mathews men earlier in the season.
St. Pat's will look to move into the top three, if they can pick up all three points away to Limerick FC.
And Peter Hutton takes charge of Derry City for the very first time tonight, as Derry City host Drogheda United.
