Following hot on the heels of Cian Healy's long term absence comes more bad injury news for Ireland.
Sean O'Brien will see a specialist on Friday after an issue came to light with his shoulder.
This shoulder injury is added to an ongoing ankle injury.
Leinster will reveal more information on Thursday.
And Keith Earls is out for up to four months.
The Munsterman will have surgery on his right knee in London and is tipped to be out for between 3/4 months.
Another booked in for surgery is Donncha Ryan who has an operation on his foot on Thursday.
Healy's already out of action for up to 6 months with severe hamstring problems.