Rory Best is out of Ireland's Test against South Africa at the Aviva Stadium on Saturday.
The hooker's struggling with a calf injury which he's not been able to shake off.
Leinster's Sean Cronin will more than likely start.
There's also a problem with Gordon D'Arcy.
The vastly experienced centre's carrying a groin strain.
It's expected Robbie Henshaw and Jared Payne will start in the centre.
