Robbie Diack makes his debut for Ireland in the opening Test against Argentina on Saturday.
The Ulsterman takes his position in the backrow.
Simon Zebo returns to the fold after being overlooked for the Six Nations.
Darren Cave slots into Brian O'Driscoll's old position with Felix Jones preferred to Rob Kearney at full back.
While number 8 Jordi Murphy makes his first start.
The Connacht duo Rodney Ah'You and Kieran Marmion are expected to make their debuts from the bench.
