Everton lost their second game in three weeks, which all but ends their dreams of playing Champions League football next season.
It ended at St. Mary's, Southampton 2. Everton 0.
Antolin Alcaraz headed past Tim Howard after just 55 seconds to give the home side the lead. Amazingly, it was another own goal that put Southampton two up.
Irish International Seamus Coleman heading across his own goal, which just crept inside the post.
Everton were without Phil Jagielka, and Sylvain Distin which left them with a real makeshift defence.
The Toffee's fought to get back into the game, but just couldn't find a way through the Southampton defence.
Arsenal play Newcastle on Monday, and a win for the Gunners will give them a four point lead with just two games to go.