Leinster will have to plan without Rob Kearney for their pivotal Champions Cup clash with Toulouse at the RDS tomorrow.
The veteran Leinster player is replaced by Jordan Larmour at full-back, Ross Byrne gets the nod at out-half after Johnny Sexton failed to shake off a calf injury.
Devin Toner, Dan Leavy and Jack McGrath will also miss the game with the table toppers of Pool 1.
Rory O’Loughlin partners Garry Ringrose in the midfield, following his impressive form for the province. Robbie Henshaw was rumoured to return but the former Connacht man will not feature tomorrow.
All 15 of Leinster's starting side have an international cap, 14 of them for Ireland.
Scott Fardy comes in for Devin Toner in the second row, with the tallest man in world rugby currently struggling with an injury.
Dave Kearney and Adam Byrne start on the wings for Leinster and both will be hoping to put in big performances to try and assure their place in the match-day squad in future big games.
Conor O’Brien could make his European debut after being named among the replacements, the 22-year-old gets a place on the bench after some impressive displays including a man of the match performance against Connacht last week.
The game will be a serious test of Leinster’s strength in depth, as Toulouse are currently in imperious form, having not lost since September.
15. Jordan Larmour
14. Adam Byrne
13. Garry Ringrose
12. Rory O’Loughlin
11. Dave Kearney
10. Ross Byrne
9. Luke McGrath
1. Cian Healy
2. Sean Cronin
3. Tadhg Furlong
4. Scott Fardy
5. James Ryan
6. Rhys Ruddock (captain)
7. Josh van der Flier
8. Jack Conan
Replacements: 16. James Tracy,17. Ed Byrne,18. Andrew Porter, 19. Ross Molony, 20. Max Deegan, 21. Jamison Gibson-Park, 22. Noel Reid, 23 . Conor O’Brien
Words by Eoin Harte