The self-isolation period for people with Covid-19 has reduced from 14 days to 10.
Guidance from the Health Protection Surveillance Centre says the full two weeks would be necessary if symptoms are still present, while it remains 14 days for close contacts.
It comes as the Government is to publish its medium term plan to deal with the disease, which will include low level fines for breaches and a five-level tier system for restrictions.
Tánaiste Leo Varadkar has said a new oversight group will also review the advice from NPHET in future.