The Health Minister has given twenty people licences to use medicinal cannabis.
The licences were applied for by their consultants, which first became available in late 2016.
Since then, 43 applications have been made by medical practitioners wanting to prescribe cannabis as a treatment.
The Department of Health says licences are only granted to consultants who agree to monitor the patient involved.
Licences are initially given for three months, with prescriptions reviewed every six months after that.
Dr. Des Crowley from the Irish College of General Practitioners says the Government don't want cannabis to become widespread.
"The fear of many including the government is that if you have too easy an access to it, it may go out to the illicit market", he said.
Earlier this week, The Health Minister downplayed fears of cannabis being legalised in Ireland.
A group of doctors have raised concerns lawmakers and the public are "downplaying its harmful effects".
Ministers will consider a report on relaxing personal possession laws in the next few weeks.
However, Simon Harris said "there is no plan to legalise" cannabis use generally.
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