The Tanaiste says proposed job cuts at Novartis in Dublin will come as a major blow to workers and their families.
Up to 400 jobs are set to be lost at the pharmaceutical company by the end of 2024.
It's part of what the firm calls a 'new focused strategy' at its Global Service Center Dublin operations.
Tanaiste Leo Varadkar says the government will make all necessary state assistance available to the workers and help them find new employment, education and training opportunities.
A statement from Novartis says: "Novartis today announced its intention to implement its focused strategy at the Novartis Global Service Center (NGSC) Dublin by end of 2024. This is a strategic decision, and part of the ongoing review of the Novartis organisation in many locations.
"Subject to consultation on the current proposals, over a phased period of time, the employee numbers in the Novartis Global Services Center Dublin may reduce from over 1,000 to approximately 600 employees.
"The new structure will be leaner and simpler. These changes could potentially impact approximately 400 positions, over a phased period.
"The NGSC Dublin will continue to play an important role as an important location, focusing on commercial and scientific niche areas."
"Major Blow"
Tanaiste Leo Varadkar says: "I extend my sympathies to all Novartis employees who have been affected by today’s announcement. Although the jobs losses are not unexpected, I know it will come as a major blow to workers and their families.
"I’m glad to see that Novartis has reiterated its commitment to Ireland, recognising the high quality of our workforce and that it will keep employees informed in as transparent and timely a manner as possible.
"I have also asked my officials and IDA Ireland to keep me informed of developments, especially regarding precisely how many roles are at risk before the end of 2024 and what the redundancy package will be.
"The Government will make all necessary State assistance available to the workers and help them find new employment, education and training opportunities. Given the nature of the work and sector involved, I would hope they can find new employment quickly.
"Although we live in uncertain times, the Government is doing everything we can to keep the economy in good health and to sustain our current record levels of employment."