Defending champions England will start with captain Owen Farrell at out-half against Scotland in their Six Nations opener on Saturday.
Ollie Lawrence will make his first Six Nations start in the centre alongside Henry Slade, while scrum-half Ben Youngs is set to earn his 105th cap
Elliot Daly is at full-back, Anthony Watson is at right-wing and Jonny May on the left-wing.
In the pack, Ellis Genge will play loose-head prop and Will Stuart at tight-head prop, with hooker Jamie George in the front row.
Locks Maro Itoje and Jonny Hill make up the tight five and the back row consists of Mark Wilson at blind-side flanker, Tom Curry at open-side with Billy Vunipola at No. 8.
Beno Obano could make his England debut after being named among the replacements.
England head coach Eddie Jones said: "We’re really looking forward to this game and getting the Guinness Six Nations back underway.
"It’s even more special to be taking part in a 150th anniversary game, it will be a good occasion.
"It was difficult to pick the 23 players. We’ve had a really good week of training, it’s been very competitive but I’ve gone with what I feel is the strongest 23 for this week.
"The Six Nations is a short tournament, it’s a real sprint so we’ll need to be on the front foot straight away. We know Scotland will be raring to go – but so will we."
England team to face Scotland:
15. Elliot Daly (Saracens, 47 caps)
14. Anthony Watson (Bath Rugby, 46 caps)
13. Henry Slade (Exeter Chiefs, 34 caps)
12. Ollie Lawrence (Worcester Warriors, 3 caps)
11. Jonny May (Gloucester Rugby, 61 caps)
10. Owen Farrell (C) (Saracens, 88 caps)
9. Ben Youngs (Leicester Tigers, 104 caps)
1. Ellis Genge (Leicester Tigers, 23 caps)
2. Jamie George (Saracens, 54 caps)
3. Will Stuart (Bath Rugby, 8 caps)
4. Maro Itoje (Saracens, 43 caps)
5. Jonny Hill (Exeter Chiefs, 4 caps)
6. Mark Wilson (Newcastle Falcons, 19 caps)
7. Tom Curry (Sale Sharks, 28 caps)
8. Billy Vunipola (Saracens, 56 caps)
Replacements:
16. Luke Cowan-Dickie (Exeter Chiefs, 26 caps)
17. Beno Obano (Bath Rugby, uncapped)
18. Harry Williams (Exeter Chiefs, 18 caps)
19. Courtney Lawes (Northampton Saints, 85 caps)
20. Ben Earl (Bristol Bears, 8 caps)
21. Dan Robson (Wasps, 7 caps)
22. George Ford (Leicester Tigers, 72 caps)
23. Max Malins (Bristol Bears, 3 caps)
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